Indian Journal of Public Health Research & Development

Mustafa Taha Mohammed ¹, Sura Mohammed Kadhim ¹, Zyad Hussein J. AL-Qaisi ², Ali Jasim Hammood ³

Affiliations
1 College of Science, Mustansiriyah University, IQ
2 Chemistry Department, College of Science, Mustansiriyah University, IQ
3 Ministry of Education, Rusafa-1, Baghdad, IQ

Abstract

Ischemic stroke may happen in different combinations of clinical ailments and these residues represent a major problem. Reactive oxygen species (ROS) have been shown to act a main action in cerebral ischemiareperfusion injury (IRI). Where reperfusion is defined as the action of restoring the flow of blood to an organ or tissue after a heart attack or stroke. Diverse therapeutic effects have been substantive for Rosmarinus Officinalis (Rosemary). In addition to, it has been offered that Rosmarinus Officinalis has covering impact versus I/R stimulate cerebral damages to diverse organs. For this cause, it sounds conceivable that the administration of Rosmarinus Officinalis might keep the brain versus the ischemia reperfusion injury. The study included knowledge the chemical components of the Rosmarinus Officinalis leaves in the watery extract and determine whether Rosmarinus Officinalis prevents ischemia-reperfusion induced stroke. Thirty rats were divided into three groups as control Group 1, IRI group Group2, and Rosmarinus Officinalis treatment group Group3. All animals underwent stroke for 30 min followed by 60 min period of reperfusion. Animals were internal infused with only 0.9% saline solution in group 2. Rats in group3 received Rosmarinus Officinalis (1 mL/kg) for two weeks with the same diet intraperitoneally, before ischemia and before reperfusion. We were the estimation of the biochemical parameters: Blood samples were taken from the rats. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) oxidative stress levels of nitric oxide (NO) and lipid peroxidation (LPO)and blood was used for the estimation of enzyme immunoassay: Interleukin-8 (IL-8), tumor necrosis factor Alpha (TNF-α), interleukin-1β (IL-1β).The results showed that the extract contains several species. The levels of enzymes and Oxidative stress in group3 were significantly lower than those in the group2.Our results suggest thatRosmarinus Officinalis treatment protects the rat brain against ischemia-reperfusion induced Cerebral injuries.

Keywords

Rosmarinus Officinalis, Ischemia/Reperfusion,Cerebral Injuries, Oxidative Stress, Antioxidant.

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Ban Hasan Taresh ¹, Ahmed Mutanabbi Abdula ¹, Mustafa Taha Mohammed ¹

Affiliations
1 Mustansiriyah University, Department of Chemistry, Baghdad, IQ

Abstract

In our attempt to exploring new class of antimicrobial and antioxidant agents, novel pyrazoline derivatives (3‑11) were synthesized and characterized by some spectroscopic method such as FTIR¹ HNMR and GCMass. The antimicrobial study of the synthesized compounds against various bacterial species. Escherichia coli klebsiella sp (gram negative), Staphylococcus epidermidis, Staphylococcus aureus (gram positive) and one fungi (candida albicans). The scavenging properties of all the synthesized derivatives were evaluated against DPPH radical by using TLC autographic assay and the scavenging activity was determined by using spectroscopic method.

Keywords

Chalcone, Pyrazoline, Schiff Bases, Antimicrobial, Antioxidant, Docking Study.

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